Found 38 matching trials
Reduced Intensity Transplantation for Severe Sickle Cell Disease
PHASE2This study is being done to test a transplant method that may have fewer si...
Location
St. Jude Children's Research Hospital
Treatments Being Tested
hydroxyurea, azathioprine, alemtuzumab, thioptepa, low dose total body irradiation and sirolimushydroxyurea, azathioprine, alemtuzumab, thiotepa, plerixafor, low dose total body irradiation, cyclophosphamide and sirolimus Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia
PHASE1Background:
Sickle cell disease (SCD) is an inherited disorder of the bloo...
Status
Active Not Recruiting
Location
National Institutes of Health Clinical Center
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease
PHASE1Background:
Peripheral blood stem cell transplantation procedures are used...
Status
Active Not Recruiting
Location
National Institutes of Health Clinical Center
Melphalan, Fludarabine, and Alemtuzumab Followed by Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer
PHASE2RATIONALE: Giving low doses of chemotherapy, such as melphalan and fludarab...
Location
Memorial Sloan-Kettering Cancer Center
Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders
PHASE2RATIONALE: Monoclonal antibodies, such as alemtuzumab, can block cancer gro...
Location
UCSF Helen Diller Family Comprehensive Cancer Center
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders
NAThis study is designed to test the ability to achieve donor hematopoietic e...
Location
Masonic Cancer Center, University of Minnesota
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody
PHASE2This multicenter prospective study seeks to determine if daratumumab given,...
Location
Children's National Hospital
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
NAThis is a standard of care treatment guideline for allogeneic hematopoetic ...
Status
Active Not Recruiting
Location
Masonic Cancer Center, University of Minnesota
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
PHASE1People with severe congenital anemias, such as sickle cell anemia and beta-...
Location
National Institutes of Health Clinical Center
Reduced Intensity Transplant Conditioning Regimen for Severe Thalassemia
PHASE2This study is being done to determine if blood cell transplants, with eithe...
Location
Regents of University of California- UCLA